Substituted dibenzofurans and methods of using same

Details Substituted dibenzofurans and methods of using same Substituted dibenzofurans and methods of using same

C - Chemistry, Metallurgy

07

D

167/208, 167/245

C07D 307/91 (2006.01) A61K 31/34 (2006.01) A61K 31/395 (2006.01) C07D 405/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2013960

Novel substituted dibenzofuran compounds are disclosed. The compounds exhibit activity in antagonizing the effects of leukotriene B4 (LTB4). Pharmaceutical compositions containing the novel compounds and methods of treatment employing the same are also described. The compounds have the general forumla: (see formula I) wherein (a) n is an integer from 1 to 5; (b) R1 is selected from the group consisting of alkyl; phenyl, substituted phenyl substituted by Cl, Br, I, -CF3, -OCH3, alkyl, -CN, -NH2, -CONH2 or NO2; Ph(CH2)n wherein n is 1-5; Ph (CH2)n wherein Ph is substituted by Cl, Br, I, -CF3, -OCH3, alkyl, -CN, -NH2, -CONH2 or NO2; and (c) R2 is selected from the group consisting of CO2 R3 wherein R3 is alkyl, aryl or aralkyl; alkanoate salt; C(O)NR4R5 wherein R4 is H, alkyl or aryl and R5=R4 or is one of the other R4 substituents, or R4 and R5 form a heterocyclic ring with the N as the sole heteroatom; tetrazole; sulfinic acid; sulfonic acid; and half esters of sulfur acids or sulfonamides derived therefrom.

Affiliated with

Also associated with

Rating

Substituted dibenzofurans and methods of using same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted dibenzofurans and methods of using same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted dibenzofurans and methods of using same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2020524