Substituted furochromenes, preparation thereof and their...

Details Substituted furochromenes, preparation thereof and their... Substituted furochromenes, preparation thereof and their...

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) A61K 31/352 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2546481

The invention relates to novel compounds of formula (I) including all their tautomers to pharmaceutically acceptable salts and solvates thereof, to processes and reactive intermediates for the preparation thereof; to processes and reactive intermediates for the preparation of compounds of formula (II) including all their stereoisomers and tautomers to the use of the compounds of the formula (II) as suitable precursors for the preparation of the compounds of the formula (I) as well as to use of the compounds of the formula (I) and of the compounds of the formula (II) as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diesases and conditions in humans.

L'invention concerne de nouveaux composés de formule (I), y compris tous leurs tautomères. L'invention concerne également des sels pharmaceutiquement acceptables et des solvates de ceux-ci. L'invention concerne des procédés et des intermédiaires réactifs pour la préparation de ceux-ci. L'invention concerne des procédés et des intermédiaires réactifs pour la préparation de composés de formule (II), y compris tous leurs stéréisomères et leurs tautomères. L'invention concerne l'utilisation des composés de formule (II) en tant que précurseurs appropriés à la préparation des composés de formule (I), ainsi que l'utilisation des composés de formule (I) et des composés de formule (II) en tant qu'agents thérapeutiquement actifs pour la prophylaxie et pour le traitement de l'asthme et d'autres maladies inflammatoires, ainsi que de troubles chez les humains.

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