C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/14 (2006.01) A61K 31/519 (2006.01)
Patent
CA 2536786
The present invention relates to tetracyclic pyrimidines or pyridines or pharmaceutically-acceptable salts or derivatives thereof. Also included are methods of use of the tetracyclic pyrimidines or pyridines including use related to treating inflammation, inhibiting T cell activation and proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease and many other related disorders in a subject, the methods comprising administering a therapeutically-effective amount a compound as described above to the subject.
La présente invention concerne des pyrimidines ou des pyridines tétracycliques ou des sels ou des dérivés pharmaceutiquement acceptables desdits composés. Elle concerne également des méthodes d'utilisation de ces pyrimidines ou pyridines tétracycliques, notamment pour traiter l'inflammation, pour inhiber l'activation et la prolifération des lymphocytes T, et pour traiter l'arthrite, la transplantation d'organes, la lésion ischémique ou la lésion de reperfusion, l'infarctus du myocarde, l'accident vasculaire cérébral, la sclérose en plaques, la maladie intestinale inflammatoire et diverses autres affections chez un sujet. Ces méthodes consistent à administrer une dose thérapeutiquement efficace d'un composé susmentionné à ce sujet.
Ermann Monika
Ghiron Chiara
Johnston David N.
Nunes Joseph J.
Saluste Carl-Gustaf Pierre
Amgen Inc.
Gowling Lafleur Henderson Llp
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