C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) C07C 317/46 (2006.01) C07C 323/62 (2006.01) C07D 209/22 (2006.01) C07D 215/14 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 491/04 (2006.01) C07D 491/052 (2006.01)
Patent
CA 2070422
2070422 9106537 PCTABS00005 There are disclosed compounds of the formula: A(CH2)nO-B, wherein A is C4-C8 alkyl, phenoxyethyl, phenoxyphenyl or a group having formula (a) or (b), wherein X is -N- or (c); Z is (d), (e), (f), (g), -S- or -O-; R1 is hydrogen, lower alkyl, phenyl or phenyl substituted with trifluoromethyl; R2 is hydrogen or lower alkyl; or R1 and R2 taken together form a benzen ring; R3 is hydrogen or lower alkyl; n is 1-2; B is (h), (i), (j) or (k); wherein R4 is -CO2R2, (l), (m), (n), (o) or (p); m is 0-3; R5 is (q); or phenyl or phenyl substituted by halo, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl; R6 is A(CH2)nO- or halo; with the proviso that when R6 is halo, R5 is (r); R7 is lower alkyl; Y is -CH2- or -O-; R8 is lower alkyl or -(CH2)mCO2R3; R9 is (s) or -CH2R10; R10 is lower alkyl, phenyl, phenyl substituted with carboxy, halo, loweralkylthio or loweralkylsulfinyl, pyridyl, furanyl or quinolinyl; R11 is lower alkyl or phenyl; and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.
Demerson Christopher A.
Failli Amedeo Arturo
Kreft Anthony F. III
Musser John H.
Nelson James A.
American Home Products Corporation
Ridout & Maybee Llp
LandOfFree
Substituted indole-, indene-, pyranoindole and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted indole-, indene-, pyranoindole and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted indole-, indene-, pyranoindole and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1446481