Substituted isoindoles as bace inhibitors and their use

Details Substituted isoindoles as bace inhibitors and their use Substituted isoindoles as bace inhibitors and their use

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/506 (2006.01) A61P 25/28 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 403/10 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2743938

The present invention relates to novel compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of A.beta.-related pathologies such as Downs syndrome, O-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer Disease, memory loss, attention deficit symptoms associated with Alzheimer disease, neurodegeneration associated with diseases such as Alzheimer disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.

L'invention concerne de nouveaux composés de formule (I) et des compositions pharmaceutiques correspondantes, ainsi que des procédés thérapeutiques pour le traitement et/ou la prévention de pathologies en rapport avec Aß du type syndrome de Downs, angiopathie ß-amyloïde pouvant être, mais pas excusivement, l'angiopathie amyloïde cérébrale ou l'hémorragie cérébrale héréditaire, de troubles associés à une déficience cognitive pouvant être, mais pas exclusivement, la déficience cognitive légère, la maladie d'Alzheimer, la perte de mémoire, de symptômes de déficit d'attention associés à la maladie d'Alzheimer, de la neurodégénérescence associée à des maladies comme la maladie d'Alzheimer ou de la démence incluant la démence d'origine mixte vasculaire et dégénérative, la démence présénile, la démence sénile et la démence associée à la maladie de Parkinson, de la paralysie supranucléaire progressive ou de la dégénérescence cortico-basale.

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