Substituted lactose derivatives as cell adhesion inhibitors

Details Substituted lactose derivatives as cell adhesion inhibitors Substituted lactose derivatives as cell adhesion inhibitors

C - Chemistry, Metallurgy

07

H

C07H 15/18 (2006.01) C07H 3/04 (2006.01) C07H 3/06 (2006.01) C07H 11/00 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2138645

Compounds and methods of making them having formula (1) are described which bind to selectin receptors and thus mod- ulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events. In formula (1), R1 is inde- pendently H or lower alkyl(1-4C); R2 is H, OH or lower alkyl(1-4C), alkylaryl or one or more additional saccharide resi- dues; R3 is a negatively charged moiety including S04--, P04--, or related group; Y is H or lower alkyl(1-4C); and X is -CHR4(CHOR1)2CHR50R1 wherein R4 and R5 are each independently H, lower alkyl(1-4C), or taken together result in a five- or six-membered ring optionally containing a heteroatom selected from the group consisting of O, S, and NR1; said five- or six-membered ring optionally substituted with one substituent selected from the group consisting of Rl, CH20R1, OR1, OOCR1, NR12, NHCOR1, and SR1 with the proviso that if X represents a hexose substituent R3 and R4, taken togeth- er, cannot provide a hexose substituent.

Affiliated with

Also associated with

Rating

Substituted lactose derivatives as cell adhesion inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted lactose derivatives as cell adhesion inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted lactose derivatives as cell adhesion inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1481770