Substituted n-alkylpyrimidinones

Details Substituted n-alkylpyrimidinones Substituted n-alkylpyrimidinones

C - Chemistry, Metallurgy

07

D

C07D 239/60 (2006.01) A61K 31/513 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07D 239/52 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2580497

This invention is directed generally to substituted pyrimidinone compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such substituted pyrimidinone include compounds generally corresponding in structure to the following formula (I): wherein R1, R2, R3, R4A, R4B, R4C, R4D and R4E are as defined in this specification. This invention also is directed to compositions of such substituted pyrimidinones (particularly pharmaceutical compositions), intermediates for the syntheses of such substituted pyrimidinones, methods for making such substituted pyrimidinones, and methods for treating (including preventing) conditions (typically pathological conditions) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity.

Cette invention concerne généralement des composés de pyrimidinones substitués qui inhibent généralement l'activité de la p38 kinase, du TNF et/ou de la cyclo-oxygénase. Ces pyrimidinones substitués comprennent des composés dont la structure correspond généralement à la formule (I) dans laquelle R1, R2, R3, R4 et R5 sont tels que définis dans le mémorandum descriptif. L'invention concerne également des compositions desdits pyrimidinones substitués et des méthodes de traitement (et de prévention) d'états (généralement pathologiques) associés à l'activité de la p38 kinase, du TNF et/ou de la cyclo-oxygénase-2.

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