Substituted phenoxy thiazolidinediones as estrogen related...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 277/34 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) C07D 263/44 (2006.01)

Patent

CA 2679944

The present invention relates to compounds of Formula (I): methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

L'invention concerne des composés représentés par la formule (I) : des procédés pour préparer ces composés, compositions, intermédiaires et dérivés de ceux-ci et pour traiter une condition comprenant sans s'y limiter la spondylarthrite ankylosante, l'athérosclérose, l'arthrite (telle que la polyarthrite rhumatoïde, l'arthrite infectieuse, l'arthrite juvénile, le rhumatisme psoriasique, l'arthrite réactive), des maladies liées aux os (comprenant celles liées à la formation osseuse), le cancer du sein (comprenant ceux qui ne répondent à un traitement anti-AEstrogénique), des troubles cardiovasculaires, une maladie liée au cartilage (telle que la lésion/perte de cartilage, la dégénération de cartilage et les maladies liées à la formation de cartilage), la chondrodysplasie, le chondrosarcome, la blessure dorsale chronique, la bronchite chronique, la maladie inflammatoire chronique des voies respiratoires, la broncho-pneumopathie chronique obstructive, le diabète, des troubles de l'homéostase énergétique, la goutte, la pseudo-goutte, les troubles lipidiques, le syndrome métabolique, le myélome multiple, l'obésité, l'arthrose, l'ostéogenèse imparfaite, la métastase osseuse ostéolytique, l'ostéomalacie, l'ostéoporose, la maladie de Paget, la parodontopathie, la pseudo-polyarthrite rhizomélique, le syndrome de Reiter, la fracture de stress à répétition, l'hyperglycémie, le niveau de glycémie élevé et la résistance à l'insuline.

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