Substituted phenyl acetic acids as dp-2 antagonists

Details Substituted phenyl acetic acids as dp-2 antagonists Substituted phenyl acetic acids as dp-2 antagonists

C - Chemistry, Metallurgy

07

D

C07D 211/96 (2006.01) A61K 31/404 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) C07D 207/48 (2006.01) C07D 209/18 (2006.01) C07D 215/58 (2006.01) C07D 217/06 (2006.01) C07D 267/14 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2654927

Substituted phenyl acetic acid compounds of formula (I), pharmaceutical compositions, methods for their preparation and methods are provided that are useful in the treatment and prevention of disorders or conditions responsive to DP-2 receptor modulation, in particular, inflammatory and immune-related disorders and conditions, such as asthma, allergic rhinitis and atopic dermatitis.

La présente invention concerne des composés d'acide phénylacétique substitués répondant à la formule I, des compositions pharmaceutiques, des procédés permettant leur préparation et des procédés qui se révèlent utiles pour le traitement et la prévention de troubles ou de pathologies sensibles à une modulation du récepteur de DP-2, en particulier, des troubles et des pathologies inflammatoires et immunitaires, tels que l'asthme, la rhinite allergique et la dermatite atopique.

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