Substituted phenyl phenol leukotriene antagonists

Details Substituted phenyl phenol leukotriene antagonists Substituted phenyl phenol leukotriene antagonists

C - Chemistry, Metallurgy

07

C

C07C 59/68 (2006.01) A61K 31/00 (2006.01) C07C 45/46 (2006.01) C07C 45/67 (2006.01) C07C 45/71 (2006.01) C07C 47/575 (2006.01) C07C 49/84 (2006.01) C07C 59/90 (2006.01) C07C 65/24 (2006.01) C07C 65/40 (2006.01) C07C 69/736 (2006.01) C07C 69/92 (2006.01) C07C 69/94 (2006.01) C07C 235/20 (2006.01) C07C 255/54 (2006.01) C07C 311/51 (2006.01) C07C 317/28 (2006.01) C07C 317/44 (2006.01) C07C 319/18 (2006.01) C07C 323/12 (2006.01) C07C 323/20 (2006.01) C07C 323/56 (2006.01) C07C 323/62 (2006.01) C07D 257/04 (2006

Patent

CA 2083639

Antagonists having a substituted phenyl phenol or a substituted phenolic biphenyl structure, and various derivatives thereof, are specific leukotriene antagonists. Their structures, use and synthesis are disclosed. Also, pharmaceutical formulations are disclosed for use in applications treating diseases or conditions characterized by excessive release of leukotriene B4, one of the metabolites of arachidonic acid. The primary LTB4 antagonistic structures are represented as: (see formula I) or a pharmaceutically acceptable base addition salt thereof, wherein R1, R2, R3, R4, X, Y, Z, and A are described in detail in this application.

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