C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2548426
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
La présente invention a trait à des composés agissant en tant qu'antagonistes efficaces du récepteur CCR1, et présentent in vivo une activité anti-inflammatoire. Les composés sont généralement des dérivés de pipérazine et sont utiles dans des compositions pharmaceutiques, des procédés pour le traitement de maladies liées au CCR1, et en tant que témoins dans des dosages pour l'identification d'antagonistes compétitifs de CCR1.
Aggen James B.
Chen Wei
Dairaghi Daniel Joseph
Mcmaster Brian E.
Pennell Andrew M. K.
Chemocentryx Inc.
Fetherstonhaugh & Co.
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