Substituted piperazines as cb1 antagonists

Details Substituted piperazines as cb1 antagonists Substituted piperazines as cb1 antagonists

C - Chemistry, Metallurgy

07

D

C07D 241/04 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61P 3/00 (2006.01) A61P 9/10 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2692268

Compounds of Formula (I) or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardio- vascular conditions.

L'invention concerne des composés de formule (I), ou des sels, des solvates ou des esters pharmaceutiquement acceptables de ceux-ci, servant à traiter des maladies ou des troubles médiés par des récepteurs CB1, notamment un syndrome métabolique et l'obésité, des troubles neuro-inflammatoires, des troubles cognitifs et psychotiques, une dépendance (par exemple, dépendance empêchant un individu de s'arrêter de fumer), des troubles gastro-intestinaux et des troubles cardio-vasculaires.

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