Substituted piperazines as cb1 antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 241/04 (2006.01) A61K 31/495 (2006.01) A61P 3/00 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2694264

Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions. Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.

L'invention concerne des composés de formule (I), ou des sels, des solvates ou des esters pharmaceutiquement acceptables de ceux-ci, servant à traiter des maladies ou des troubles médiés par des récepteurs CB1, notamment un syndrome métabolique et l'obésité, des troubles neuro-inflammatoires, des troubles cognitifs et psychotiques, une dépendance (par exemple, dépendance empêchant un individu de s'arrêter de fumer), des troubles gastro-intestinaux et des troubles cardio-vasculaires.

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