C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/18 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) C07D 471/16 (2006.01) C07D 498/16 (2006.01) C07D 498/18 (2006.01) C07D 513/16 (2006.01)
Patent
CA 2432185
The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, R8, R9, X, b, k, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.
L'invention concerne certains nouveaux composés représentés par la formule développée (I) ou des formes de sels de ceux-ci acceptable sur le plan pharmaceutique, R?1¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, X, b, k, et n, ainsi que les lignes en pointillés étant décrits dans la demande. Cette invention concerne également des préparations pharmaceutiques comprenant ces nouveaux composés en tant que principes actifs et l'utilisation de ces nouveaux composés et de leurs préparations dans le traitement de certaines affections. Ces composés sont des agonistes et des antagonistes de sérotonine et servent à traiter ou à prévenir les troubles du système nerveux central tels que obésité, anxiété, dépression, psychose, schizophrénie, troubles du sommeil, troubles sexuels, migraines, états associés aux douleurs céphaliques, phobies sociales et troubles gastro-intestinaux, tels que les dysfonctionnements de la motilité du tube digestif.
Cacciola Joseph
Chen Wenting
Fevig John M.
Lee Taekyu
Mitchell Ian S.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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