Substituted pyridones as inhibitors of poly(adp-ribose)...

Details Substituted pyridones as inhibitors of poly(adp-ribose)... Substituted pyridones as inhibitors of poly(adp-ribose)...

C - Chemistry, Metallurgy

07

D

C07D 409/14 (2006.01) A61K 31/4412 (2006.01) A61K 31/4427 (2006.01) A61K 31/5377 (2006.01) C07D 213/64 (2006.01) C07D 217/24 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 413/10 (2006.01)

Patent

CA 2561280

The present invention discloses and claims a series of 2,3,5-substituted pyridone derivatives as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5'-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

La présente invention concerne une série de dérivés de pyridone 2,3,5-substitués tels que définis dans les revendications. L'invention concerne également des méthodes de fabrication desdits composés. Les composés de l'invention sont des inhibiteurs de la poly(adénosine 5'-diphosphate ribose) polymérase (PARP) et sont ainsi utilisés comme agents pharmaceutiques, en particulier dans le traitement et/ou la prévention de diverses maladies, y compris les maladies associées au système nerveux central et aux troubles cardiovasculaires.

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