C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/06 (2006.01) A61K 31/40 (2006.01) C07D 207/34 (2006.01)
Patent
CA 2526730
The present invention relates to substituted pyrrole derivatives of formula I, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms. Its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, prodrugs, metabolites, polymorphs, tautomers, racemates, pure enantiomers, diastereoisomers or N-oxides wherein Formula (II).
La présente invention concerne des dérivés pyrroliques substitués pouvant être utilisés comme inhibiteurs de la 3-hydroxy-3-méthylglutaryl-coenzyme A (HMG-CoA) réductase. Ces composés peuvent faire office d'hypocholestérolémiants et s'utiliser pour le traitement des maladies liées au cholestérol et des symptômes apparentés. L'invention concerne des procédés pour la préparation de ces composés, ainsi que des compositions pharmaceutiques les contenant, et des méthodes pour traiter les maladies liées au cholestérol et les symptômes apparentés.
Aryan Ram Chander
Chugh Anita
Kumar Yatendra
Ramanathan Vikram Krishna
Salman Mohammad
Deeth Williams Wall Llp
Ranbaxy Laboratories Limited
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