Substituted pyrrolidinones having an antithrombotic effect,...

Details Substituted pyrrolidinones having an antithrombotic effect,... Substituted pyrrolidinones having an antithrombotic effect,...

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/4025 (2006.01) A61K 31/454 (2006.01) A61K 31/5355 (2006.01) A61K 31/549 (2006.01) A61K 31/551 (2006.01) A61K 31/553 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2592131

The invention relates to novel substituted pyrrolidinones of general formula (I), in which A, X, B and R1 to R9 are defined as in Claim 1, to their tautomers, enantiomers, diastereomers, mixtures and their salts, particularly their physiologically compatible salts with inorganic or organic acids or bases, which have valuable properties, in particular, an antithrombotic effect and a factor xa-inhibitory effect.

L'invention concerne de nouvelles pyrrolidinones substituées de formule générale (I), dans laquelle A, X, B et R1 à R9 sont définis à la revendication 1, leurs tautomères, leurs énantiomères, leurs diastéréoisomères, leurs mélanges et leurs sels, notamment leurs sels physiologiquement acceptables avec des sels ou des bases inorganiques ou organiques. Ces nouvelles pyrrolidinones présentent des propriétés intéressantes, notamment un effet antithrombotique et inhibiteur du facteur Xa.

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