C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/226, 260/281
C07D 215/14 (2006.01) A61K 31/47 (2006.01) C07D 215/16 (2006.01)
Patent
CA 2017135
A quinolin-2-yl-methoxy)phenylacyl-sulphonamide or -cyanamide of the formula (SEE FORMULA I) in which A, B, D, E, L and G are identical or different and - represent hydrogen, hydroxyl, halogen, carboxyl, Nitro, trifluoromethyl, trifluoromethoxy or a group of the formula -NR3R4, in which R3 and R4 are identical or different and denote hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms or aryl having 6 to 10 carbon atoms, - represent straight-chain or branched alkyl, alkoxy or alkoxycarbonyl in each case having up to 12 carbon atoms, - represent aryl having 6 to 10 carbon atoms, R1 - represents cycloalkyl having 3 to 8 carbon atoms, R2 - represents hydrogen or - straight-chain or branched alkyl having up to 10 carbon atoms, - represents an alkali metal, - represents cycloalkyl having 3 to 8 carbon atoms, X - represents a group of the formula -SO2-R5, in which R5 - denotes trifluoromethyl or straight-chain or branched alkyl having up to 10 carbon atoms, or - denotes aryl having 6 to 10 carbon atoms, or X - represents cyano and physiologically acceptable salts thereof. The (quinolin-2-yl-methoxy)phenylacylsulphonamide or -cyanamide is useful as an active compound in medica- ments, particularly as a lipoxygenase inhibitor.
Fruchtmann Romanis
Kohlsdorfer Christian
Mohrs Klaus-Helmut
Muller-Peddinghaus Reiner
Raddatz Siegfried
Aktiengesellschaft Bayer
Fetherstonhaugh & Co.
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