Substituted styrene derivatives

Details Substituted styrene derivatives Substituted styrene derivatives

C - Chemistry, Metallurgy

07

C

167/208, 167/276

C07C 251/58 (2006.01) A61K 31/15 (2006.01) C07C 251/44 (2006.01) C07D 295/088 (2006.01) C07D 295/13 (2006.01)

Patent

CA 1326484

SUBSTITUTED STYRENE DERIVATIVES A b s t r a c t The new compounds of the general Formula I Image (wherein A stands for a C2-4 straight or branched chain alkylene group; R1 and R2 may be same or different and each stands for hydrogen, halogen, lower alkyl or lower alkoxy; or R1 and R2 together form a methylenedioxy group; R3 and R4 may be the same or different and each stands for C1-5 alkyl or C3-6 cycloalkyl or R3 and R4 together with the nitrogen atom, they are attached to, form a 4-7 membered ring which may contain as additional ring member an oxygen or sulfur atom or a further nitrogen atom and the latter nitrogen atom may optionally bear a C1-3 alkyl or benzyl substituent) - 2 - and pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof possess valuable therapeutical properties and exert particularly useful tranquillant-sedative, antidepressant, antiepileptic, anti- parkinson, analgesic, local anaesthetic, gastric acid secretion inhibiting and/or antianginal effect. The new compounds of the general Formula I may be prepared by methods known per se.

587330

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