C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/52 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 3/04 (2006.01) C07D 239/42 (2006.01) C07D 277/42 (2006.01) C07D 277/46 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2562075
The present invention provides substituted thiazole and pyrimidine derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
L'invention concerne des dérivés hétéroaryle substitués de formule (I), des procédés d'élaboration correspondants, des compositions pharmaceutiques renfermant les composés de formule (I), et des procédés d'utilisation correspondants pour le traitement de troubles chez l'homme ou l'animal. Les composés considérés peuvent être utiles comme inhibiteurs de l'action de l'AgRP sur le récepteur de la mélanocortine, et donc utiles pour la gestion, le traitement, le contrôle ou le traitement auxiliaire de maladies qui peuvent réagir à la modulation des récepteurs de la mélanocortine, y compris les troubles liés à l'obésité.
Andrews Robert C.
Arimilli Murty N.
Dankwardt John
Gaddam Bapu R.
Mjalli Adnan M. M.
Moffat & Co.
Transtech Pharma Inc.
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