A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2413802
The invention provides a method of treating of inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.
L'invention concerne un procédé de traitement et d'inhibition de la croissance de cellules de tumeur cancéreuse et d'affections associées chez un mammifère nécessitant un tel traitement. Ce procédé consiste à administrer audit mammifère une quantité efficace de dérivé de triazolopyrimidine substitué ou d'un sel pharmaceutiquement acceptable de celui-ci. Par ailleurs, l'invention concerne également un procédé de traitement ou d'inhibition de la croissance de cellules de tumeur cancéreuse et d'affections associées chez un mammifère nécessitant un tel traitement, interagissant avec de la tubuline et des microtubules et développant la polymérisation microtubulaire qui comprend l'administration audit mammifère d'une quantité efficace de dérivé de triazolopyrimidine substitué ou d'un sel pharmaceutiquement acceptable de celui-ci.
Albert Guido
Beyer Carl F.
Carter Paul
Harris Jane E.
Kirsch Donald R.
Ridout & Maybee Llp
Wyeth
LandOfFree
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