Sulfonamide-containing heterocyclic compounds

Details Sulfonamide-containing heterocyclic compounds Sulfonamide-containing heterocyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 215/38 (2006.01) A61K 31/352 (2006.01) A61K 31/4375 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61K 31/501 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 215/48 (2006.01) C07D 217/02 (2006.01) C07D 217/22 (2006.01) C07D 217/24 (2006.01) C07D 217/26 (2006.01) C07D 311/16 (2006.01) C07D 311/18 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12

Patent

CA 2395772

A sulfonamide-containing: (see formula I) wherein: A is a hydrogen atom, a halogen atom, a hydroxyl group, a C1-C4 alkyl or alkoxy group which may be substituted or a C2-C4 alkenyl group which may have a substituent; B is a phenyl or monocyclic heteroaryl group which may be substituted: (see formula II) wherein, the ring M is a 5 or 6 membered monounsaturated carbocycle; K is a single bond or -(CR4R5)m-; one of T, U, V, W, X and Y is a nitrogen atom and the others are each =C(D)- (wherein D is a hydrogen atom, a halogen atom, a C1-C4 alkyl which may be substituted, a cyano group, -(CO)n NR6R7 and n means 0 or 1), or a C2-C4 alkenyl group which may have a substituent); Z is a single bond; R1 is a hydrogen atom; and ~ means a single or double bond, wherein R4, R5, R6 and R7 are a hydrogen atom or a C1-C4 alkyl group.

L'invention concerne des composés hétérocycliques contenant des groupes de sulfonylurée ou de sulfamide, notamment des composés hétérocycliques de formule générale (I), des sels correspondants acceptables sur le plan pharmaceutique, ou des hydrates desdits composés et sels. Dans la formule générale (I), A représente l'hydrogène, un halogène, facultativement C¿1-4? alkyle ou similaire, B représente un aryle substitué facultativement, un hétéroaryle monocyclique, ou similaire, K est une liaison unique ou similaire, T, W, X et Y représentent respectivement =C(D) - (où D représente l'hydrogène, un halogène ou similaire) ou l'azote, U et V représentent respectivement =C(D) -, l'azote, l'oxygène ou similaire, Z représente une liaison unique ou-CO-NH-, et R¿1? représente l'hydrogène ou similaire.

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