Sulfonamide derivatives

Details Sulfonamide derivatives Sulfonamide derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/76 (2006.01) A61K 31/18 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) A61K 31/70 (2006.01) C07C 311/21 (2006.01) C07C 311/29 (2006.01) C07C 311/44 (2006.01) C07D 213/74 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 239/42 (2006.01) C07D 239/48 (2006.01) C07D 239/50 (2006.01) C07D 307/68 (2006.01) C07D 333/38 (2006.01) C07F 9/58 (2006.01) C07H 15/203 (2006.01) C07H 15/26 (2006.01)

Patent

CA 2049496

Novel sulfonamide derivatives and pharmacologically acceptable salts thereof are disclosed having excellent antitumor activity and low toxicity, as well as processes for producing them. The sulfonamide derivatives fall within the general formula: Image (I) wherein preferably R1 represents a lower alkoxy group, R2 , R3 , R4, R5, R6, and R7 may be the same or different from one another and each represents a hydrogen atom, halogen atom or lower alkyl group, A and B may be the same or different from each other and each represents =N- or =CH-, E represents an aromatic 6-membered cyclic group (which may have 1 or 2 nitrogen atoms in the ring) which may be substituted with 1 to 3 substituents which may be the same or different from one another with the proviso that a combination in which R1 is a hydrogen atom, lower alkyl group, nitro group or amino group which may be protected, R2 and R3 are each a hydrogen atom, A and B are each =CH- and E is a phenyl group which may be substituted with 1 to 3 substituents g which may be the same or different from one another is excluded.

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