Sulfone substituted 2,3-dihydroimidazo [1,2-c] quinazoline...

Details Sulfone substituted 2,3-dihydroimidazo [1,2-c] quinazoline... Sulfone substituted 2,3-dihydroimidazo [1,2-c] quinazoline...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2713388

This invention relates to novel sulfone 2I3-dihydroimidazo[1 12-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (P13K) in-hibition and treating diseases associated with phosphotidylinositol-3- kinase (P13K) activity, in particular treating hyper-proliferative and/or angiogenesis mediated disorders, as a sole agent or in combination with other active ingredients.

Cette invention concerne des nouveaux composés 2,3-dihydroimidazo[1,2-c]quinazoline sulfone, des compositions pharmaceutiques contenant ces composés et l'utilisation de ces composés ou de ces compositions pour inhiber la phosphotidylinositol-3-kinase (PI3K) et traiter des maladies associées à l'activité de phosphotidylinositol-3-kinase (PI3K), en particulier, pour traiter des troubles hyperproliférants et/ou induits par l'angiogénèse, comme agent unique ou combinés avec d'autres ingrédients actifs.

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