Sulphonamide derivatives as aspartyl protease inhibitors

Details Sulphonamide derivatives as aspartyl protease inhibitors Sulphonamide derivatives as aspartyl protease inhibitors

C - Chemistry, Metallurgy

07

C

C07C 311/29 (2006.01) A61K 31/18 (2006.01) A61K 31/27 (2006.01) A61K 31/395 (2006.01) C07C 311/41 (2006.01) C07D 211/60 (2006.01) C07D 213/30 (2006.01) C07D 213/34 (2006.01) C07D 213/70 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 217/24 (2006.01) C07D 217/26 (2006.01) C07D 231/38 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 233/76 (2006.01) C07D 233/84 (2006.01) C07D 233/88 (2006.01) C07D 233/90 (2006.01) C07D 235/06 (2006.01) C07D 235/28 (2006.01) C07D 241/04 (2006.01) C07D 249

Patent

CA 2183653

This invention relates to a novel class of sulfonamides that are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of aspartyl protease inhibitors characterized by specific structural and physiochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting aspartyl protease activity and methods for treating viral infections using the compounds and compositions of this invention.

L'invention concerne une nouvelle catégorie de sulfamides qui sont des inhibiteurs de protéase d'aspartyle. Dans un mode de réalisation, cette invention concerne une nouvelle catégorie d'inhibiteurs de protéase d'aspartyle présentant des caractéristiques spécifiques structurelles et physicochimiques. Elle concerne également des compositions pharmaceutiques comprenant lesdits composés. Ces composés et ces compositions pharmaceutiques sont particulièrement bien appropriés pour inhiber l'activité de protéase de VIH-1 et VIH-2 et peuvent, par conséquent, s'utiliser avantageusement en tant qu'agents antiviraux contre les virus de VIH-1 et VIH-2. L'invention concerne encore des procédés servant à inhiber l'activité de protéase d'aspartyle, ainsi que des procédés de traitement d'infections virales au moyen desdits composés et desdites compositions.

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