Sulphonamido-substituted bridged bicycloalkyl derivatives

Details Sulphonamido-substituted bridged bicycloalkyl derivatives Sulphonamido-substituted bridged bicycloalkyl derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/07 (2006.01) A61K 31/18 (2006.01) A61K 31/40 (2006.01) A61P 25/28 (2006.01) C07C 311/09 (2006.01) C07C 311/11 (2006.01) C07C 311/14 (2006.01) C07C 311/20 (2006.01) C07C 311/24 (2006.01) C07C 323/67 (2006.01) C07D 207/36 (2006.01) C07D 211/14 (2006.01) C07D 211/18 (2006.01) C07D 213/30 (2006.01) C07D 213/38 (2006.01) C07D 213/70 (2006.01) C07D 213/71 (2006.01) C07D 213/81 (2006.01) C07D 215/12 (2006.01) C07D 215/20 (2006.01) C07D 223/32 (2006.01) C07D 233/84 (2006.01) C07D 249/08 (2006.01) C07D 271/

Patent

CA 2404125

A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures of formula (I) (where the variables are as defined in the claims). The compounds are inhibitors of .gamma.-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.

Cette invention a trait à une classe de composés, comportant des structures bicycloalkyles pontées à substitution sulphonamido correspondant à la formule (I), formule dans laquelle les variables sont telles que définies dans les revendications. Ces composés, qui sont des inhibiteurs de la secrétase-.gamma., se révèlent, de ce fait, des plus utiles en matière de traitement et/ou de prévention de la maladie d'Alzheimer.

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