Surfactant protein d for the prevention and diagnosis of...

Details Surfactant protein d for the prevention and diagnosis of... Surfactant protein d for the prevention and diagnosis of...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61P 11/00 (2006.01) C07K 14/785 (2006.01) C12Q 1/68 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2749553

Surfactant protein D(SP-D) is a 43-kDa member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene was targeted by homologous recombination in embryonic stem cells that were used to produce SP-D (-/-) mice. The SP-D (-/-) deficiency caused inflammation, increased oxidant production by isolated alveolar macrophages, abnormal surfactant structure and levels, and decreased SP-A expression. Therefore, disclosed is the SP-D (-/-) mouse as an excellent model for emphysema. Also included are models for testing emphysema therapies in the mouse model, methods for using SP-D protein or DNA as a treatment for emphysema and pulmonary infections, and diagnosis.

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