Susceptibility gene for inflammatory bowel disease

Details Susceptibility gene for inflammatory bowel disease Susceptibility gene for inflammatory bowel disease

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 39/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2385381

An association between a 32bp deletion in the human gene encoding chemokine receptor CCR5 and the development of inflammatory bowel disease, (IBD), in particular Crohn's disease and ulcerative colitis is described. Methods of diagnosis of susceptibility to IBD and of distinguishing between Crohn's disease and ulcerative colitis are provided which involve detection of the CCR5-.DELTA.32 allele in patients suffering from, or suspected of developing, IBD. Screening methods suitable for identifying molecules with potential as therapeutic agents against IBD are also described.

Il est possible d'établir une relation entre une délétion 32bp du gène humain codant pour le récepteur CCR5 de la chémokine, et le développement d'une affection intestinale inflammatoire (IBD), en particulier la maladie de Crohn' et la colite ulcéreuse. L'invention concerne des techniques permettant de diagnostiquer une susceptibilité à IBD, et d'établir une distinction entre la maladie de Crohn et la colite ulcéreuse, ce qui implique la détection de l'allèle CCR5-.DELTA.32 chez des patients qui en souffrent ou qui sont suspectés de développer une IBD. L'invention concerne également des techniques de criblage appropriées pour identifier des molécules ayant un potentiel en tant qu'agents thérapeutiques contre une IBD.

Affiliated with

Also associated with

Rating

Susceptibility gene for inflammatory bowel disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Susceptibility gene for inflammatory bowel disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Susceptibility gene for inflammatory bowel disease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1343110