Sustained release bolus effective for the prolonged...

Details Sustained release bolus effective for the prolonged... Sustained release bolus effective for the prolonged...

A - Human Necessities

61

K

167/244

A61K 31/365 (2006.01) A61K 9/00 (2006.01) A61K 31/425 (2006.01)

Patent

CA 2010934

A sustained release bolus composition, containing a prophylactically effective amount of a compound selected from LL-F28249.alpha., 23-(O-methyloxime)- LL-F28249.alpha. and derivatives thereof provides a method for protecting ruminant animals for a prolonged period of time against infestation by nematodes, acarids and endo- and ectoparasitic insects, and which over time can also eliminate the initial population of parasites present at treatment. The invention also relates to a method for the systemic control of ectoparasitic insect infestations of ruminant animals by orally administering to said animals a sustained release bolus containing an insecticidally effective amount of LL-F28249.alpha., 23-(O-methyloxime)LL-F28249.alpha. or derivative thereof, which continuously releases into the rumen of the treated animal a systemically effective amount of LL-F28249.alpha., 23-(O-methyloxime)LL-F28249.alpha. or derivative thereof.

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