Sustained-release compositions and method for preparing same

A - Human Necessities – 61 – K

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Details

A61K 38/08 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/19 (2006.01) A61K 9/50 (2006.01) A61K 31/713 (2006.01) A61K 38/09 (2006.01) A61K 47/30 (2006.01) C07K 7/23 (2006.01) C07K 14/655 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2286575

The invention concerns compositions in the form of microcapsules or implants comprising a biodegradable polymer or copolymer vehicle or mixture of vehicles with logarithmic viscosity number between 0.5 dl/g and 1.6 dl/g in CHCl¿3? and an active substance or mixture of active substances, said microcapsules or implants being capable of releasing the active substance or mixture of active substances over a prolonged period up to three months or more. These compositions can also comprise an active substance with high specific surface area.

L'invention concerne des compositions sous forme de microcapsules ou d'implants comprenant un excipient ou un mélange d'excipients polymères ou copolymères biodégradables de viscosité inhérente comprise entre 0.5 dl/g et 1,6 dl/g dans CHCl3 et une substance active ou un mélange de substances actives, lesdits microcapsules ou implants pouvant libérer la substance active ou le mélange de substances actives sur une période prolongée pouvant aller jusqu'à trois mois ou plus. Ces compositions peuvent également comporter un principe actif présentant une surface spécifique élevée.

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