C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) A61K 35/00 (2006.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 48/00 (2006.01) C12N 15/85 (2006.01) C12P 19/34 (2006.01) G01N 33/00 (2006.01)
Patent
CA 2397931
Miniature swine whose genomes contain sequences characteristic of pig endogenous retrovirus genes but which are non-infectious to humans are disclosed as sources of organs, tissues and cells for introduction into human recipients afflicted with diseases, or at risk of diseases, whose etiology involves the presence of inadequately functioning organs and for which xenotransplantation of such organs, tissues and cells would have a palliative effect. Methods of producing such animals and for screening animals for the desired properties are also disclosed.
L'invention concerne des porcs miniatures, dont le génome renferme des séquences caractéristiques des gènes du rétrovirus endogène porcin mais non infectieuses pour les humains, et que l'on utilise comme sources d'organes, de tissus et de cellules destinés à être introduits chez des receveurs humains atteints de maladies, ou susceptibles de contracter des maladies, qui, étiologiquement, impliquent la présence d'organes fonctionnant de manière inadéquate et pour lesquelles la xénotransplantation desdits organes, tissus et cellules auraient un effet palliatif. L'invention concerne également des méthodes de production desdits animaux, ainsi que des méthodes de criblage d'animaux possédant les propriétés recherchées.
Biotransplant Inc.
Immerge Biotherapeutics Ag
Smart & Biggar
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