Syndecan stimulation of cellular differentiation

Details Syndecan stimulation of cellular differentiation Syndecan stimulation of cellular differentiation

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/135 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) A61K 7/06 (1995.01)

Patent

CA 2150714

Methods are provided for altering levels of syadocan within a cell. The methods include enhancing syndacan expression via administration of growth factors, preventing suppression of syndecan expression via administration of anti-steroid agents, and altering syndecan biochemistry within the cell. The methods are used to induce or maintain cellular differentiation, and to decrease die growth of malignant cells. Application of the methods to the treatment of patients, including humans, is provided.

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