Synthesis of ccr5 receptor antagonists

Details Synthesis of ccr5 receptor antagonists Synthesis of ccr5 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) C07D 211/26 (2006.01)

Patent

CA 2594114

The present invention is directed to the synthesis of 4-[4-[(R)-[1- [cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1- piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.

La présente invention concerne la synthèse de 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-pipéridinyl](3-fluorophényl)méthyl]-3(S)-méthyl-1-pipérazinyl]-1-[(4,6-diméthyl-5-pyrimidinyl)carbonyl]-4-méthylpipéridine], ainsi que des intermédiaires correspondants à partir de matériaux de départ facilement disponibles par une nouvelle voie.

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