Synthesis of phenoxyacetic acid derivatives

Details Synthesis of phenoxyacetic acid derivatives Synthesis of phenoxyacetic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 43/315 (2006.01) C07C 69/734 (2006.01) C07C 213/02 (2006.01) C07C 217/60 (2006.01) C07C 233/43 (2006.01) C07C 235/06 (2006.01) C07C 235/60 (2006.01)

Patent

CA 2585037

The present invention relates to an improved process for the preparation of substituted 2-(4-carbonylmethoxy-optionally 2,5-disubstituted-phenyl)- acetaldehydes, in particular 2-(4-alkoxycarbonylmethoxy- optionally 2,5- disubstituted-phenyl)-acetaldehydes and their use in the synthesis of optionally substituted 2-[4-[2-[[-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]- amino]ethyl]- optionally 2,5-disubstituted-phenoxy]acetic acid derivatives or the salts thereof, which may be used as pharmaceutically active substances.

La présente invention concerne une amélioration approtée à un procédé d'élaboration de 2-(4-carbonylméthoxy- optionnellement 2,5-disubstitué-phényl)-acétaldehydes, et plus particulièrement de 2-(4-alcoxycarbonyl-méthoxy- optionnellement 2,5-disubstitué-phényl)-acétaldehydes, et leur utilisation pour la synthèse de dérivés d'acide 2-[4-[2-[[-2-hydroxy-2-(4-hydroxyphényl)-1-méthyléthyl]-amino]éthyl]- optionnellement 2,5-disubstituté-phénoxy]acétique, ou de certains de leurs sels, tous susceptibles de convenir comme substances pharmaceutiquement actives.

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