Synthetic active peptide fragments

Details Synthetic active peptide fragments Synthetic active peptide fragments

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/17 (2006.01) G01N 33/53 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2480494

The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequence of specific portions of the 14 kDa protein of S.mansoni (Sm14) or related FABPs (Fatty Acid Binding Proteins), the said peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic composition and diagnostic kit using said peptide fragments.

La présente invention concerne des fragments de peptides qui ont au moins une séquence d'acides aminés similaire et/ou partagée par rapport à une séquence d'acides aminés de parties spécifiques de la protéine 14 kDa de S. mansoni (Sm14) ou de protéines associées de liaisons aux acides gras (FABPS), lesdits fragments de peptides fonctionnant comme des régions épitopiques continues ou discontinues de la molécule ou imitant son activité biologique. Plus particulièrement, cette invention a trait à une méthode permettant d'élaborer des fragments de peptides actifs, des fragments de peptides, une composition immunogénique et un kit diagnostique au moyen desdits fragments de peptides.

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