Synthetic matrix metalloprotease inhibitors and uses thereof

Details Synthetic matrix metalloprotease inhibitors and uses thereof Synthetic matrix metalloprotease inhibitors and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 5/065 (2006.01) A61K 31/00 (2006.01) A61K 31/165 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 38/05 (2006.01) C07C 67/08 (2006.01) C07C 69/34 (2006.01) C07D 209/20 (2006.01) C07D 209/26 (2006.01) C07D 401/12 (2006.01) C07K 5/072 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2158760

Synthetic mammalian matrix metalloprotease inhibitors are disclosed that are useful for treating or preventing diseases wherein said diseases are caused by unwanted mammalian matrix metalloprotease activity and include skin disorders, keratoconus, restenosis, rheumatoid arthritis, wounds, cancer, angiogenesis and shock.

La présente invention concerne des inhibiteurs synthétiques de métalloprotéases matricielles des mammifères. Ces inhibiteurs conviennent particulièrement au traitement et à la prévention d'affections dans le cas où lesdites affections sont provoquées par l'activité non souhaitée de métalloprotéases matricielles des mammifères, ces affections incluant les affections cutanées, le kératocône, la resténose, la polyarthrite rhumatoïde, les lésions, le cancer, l'angiogenèse et l'état de choc.

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