Synthetic peptide immunogens and antibodies thereto

Details Synthetic peptide immunogens and antibodies thereto Synthetic peptide immunogens and antibodies thereto

A - Human Necessities

61

K

A61K 39/385 (2006.01) C07K 14/705 (2006.01) C07K 14/745 (2006.01) C07K 16/00 (2006.01) C07K 16/36 (2006.01) C07K 16/40 (2006.01) C07K 17/00 (2006.01) C12P 21/00 (2006.01) G01N 33/48 (2006.01)

Patent

CA 2339404

Provided are methods for selecting peptide immunogens for a target protein from a first species which has an amino acid sequence different from the analogous protein from a second species. The method comprises selecting peptide fragments from the target protein which are hydrophilic and which vary in sequence from the analogous protein by at least one amino acid. Antibodies made using the selected immunogens conjugated to a carrier molecule are also provided. Antibodies made by this method to rabbit tissue factor which do not cross-react with human tissue factor are also provided.

La présente invention concerne des procédés permettant de sélectionner des immunogènes peptidiques pour une protéine cible issue d'une première espèce dont une séquence d'acide aminé est différente de la protéine analogue issue d'une seconde espèce. Le procédé consiste à sélectionner des fragments de peptide de la protéine cible qui soient hydrophiles et dont la séquence s'écarte de la séquence de la protéine analogue par au moins un acide aminé. L'invention concerne également des anticorps faits en utilisant les immunogènes sélectionnés conjugués à une molécule porteuse. L'invention concerne en outre des anticorps faits selon ce procédé sur un facteur tissulaire du lapin qui n'inter-réagit pas avec un facteur tissulaire humain.

Affiliated with

Also associated with

Rating

Synthetic peptide immunogens and antibodies thereto does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic peptide immunogens and antibodies thereto, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic peptide immunogens and antibodies thereto will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2024197