Synthetic peptides and pseudopeptides having osteogenic...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/64 (2006.01) A61K 38/04 (2006.01) A61K 38/12 (2006.01) C07K 5/065 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) C07K 5/103 (2006.01) C07K 5/12 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 7/50 (2006.01) C07K 7/52 (2006.01) C07K 14/51 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2248630

The invention relates to synthetic pseudopeptide derivatives of osteogenic growth polypeptide (OGP) and OGP (10-14) which may be linear or cyclic, and which are capable of enhancing bone cell proliferation and bone formation. Further, the present invention relates to pharmaceutical composition comprising as active ingredient at least one pseudopeptide derivative of the invention and to the use of these pseudopeptide derivatives in the preparation of a pharmaceutical composition for stimulating the formation of osteoblastic or fibroblastic cells, enhancing bone formation in osteopenic pathological conditions, repairing fractures, healing wounds, grafting of intraosseous implants, reversing bone loss in osteoporosis and other conditions requiring enhanced bone cells formation.

L'invention concerne des dérivés pseudopeptidiques synthétiques du polypeptide (OGP) et OGP(10-14) de croissance ostéogénique, lesquels peuvent être linéaires ou cycliques et peuvent accroître la prolifération des cellules osseuses et la formation osseuse. En outre, la présente invention se rapporte à une composition pharmaceutique comprenant en tant que principe actif au moins un dérivé pseudopeptidique de l'invention, ainsi qu'à l'utilisation de ces dérivés pseudopeptidiques dans la préparation d'une composition pharmaceutique destinée à stimuler la formation de cellules ostéoblastiques ou fibroblastiques, à accroître la formation osseuse dans des états pathologiques d'ostéopénie, lors de greffes d'implants intra-osseux, dans la réparation de fractures et la cicatrisation de lésions, et à neutraliser la perte osseuse dans l'ostéoporose et dans d'autres états nécessitant une formation accrue de cellules osseuses.

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