Synthetic peptides capable of stimulating a t-cellular immunity

Details Synthetic peptides capable of stimulating a t-cellular immunity Synthetic peptides capable of stimulating a t-cellular immunity

C - Chemistry, Metallurgy

07

K

167/137, 530/7.0

C07K 14/235 (2006.01) A61K 39/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2017180

SYNTHETIC PEPTIDES CAPABLE OF STIMULATING A T-CELLULAR IMMUNITY Abstract The S1 subunit regions of pertussis toxin from Bordetella pertussis comprising the antigenic sites recognized by the human T helper clones anti-S1 are described and said sites are characterized. Synthetic peptides having an amino acid sequence corresponding to the sequence of said regions or of the T-epitopes comprised therein are novel. Said peptides, alone or in combination with the immunodominant B- epitope of the pertussis toxin S1 subunit from Bordetella pertussis, are particularly useful as immunogens for manufacturing acellular anti-pertussis vaccines.

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