System and method of predicting future fractures

G - Physics – 06 – T

Patent

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G06T 7/00 (2006.01) A61B 5/00 (2006.01)

Patent

CA 2580726

Methods of predicting fracture risk of a patient include: obtaining an image of a bone of the patient; determining one or more bone structure parameters; predicting a fracture line with the bone structure parameter; predicting a fracture load at which a fracture will happen; estimating body habitus of the patient; calculating a peak impact force on the bone when the patient falls; and predicting a fracture risk by calculating the ratio between the peak impact force and the fracture load. Inventive methods also includes determining the effect of a candidate agent on any subject's risk of fracture.

La présente invention se rapporte à des procédés permettant de prédire le risque de fracture d'un patient. Lesdits procédés consistent : à obtenir une image d'un os du patient ; à déterminer un ou plusieurs paramètres de structure osseuse ; à prédire une ligne de fracture à l'aide du paramètre de structure osseuse ; à prédire une charge de fracture, à laquelle une fracture se produira ; à estimer l'habitus corporel du patient ; à calculer une force de choc maximum sur l'os lors d'une chute du patient ; et à prédire un risque de fracture, en calculant le rapport entre la force de choc maximum et la charge de fracture. Des procédés selon l'invention consistent également à déterminer l'effet d'un agent candidat sur le risque de fracture d'un sujet quelconque.

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