C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 40/06 (2006.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01)
Patent
CA 2725978
A system for expression-based discrimination of distinct clinical disease states in prostate cancer is provided that is based on the identification of sets of gene transcripts, which are characterized in that changes in expression of each gene transcript within a set of gene transcripts can be correlated with recurrent or non-recurrent prostate cancer. The Prostate Cancer Prognostic system provides for sets of "prostate cancer prognostic" target sequences and further provides for combinations of polynucleotide probes and primers derived there from. These combinations of polynucleotide probes can be provided in solution or as an array. The combination of probes and the arrays can be used for diagnosis. The invention further provides further methods of classifying prostate cancer tissue.
La présente invention concerne un système de discrimination basée sur lexpression détats pathologiques cliniques distincts dans le cancer de la prostate. Ledit système repose sur lidentification densembles de transcriptions de gène, qui se caractérise en ce que des changements dans lexpression de chaque transcription de gène au sein dun ensemble de transcriptions de gène peuvent être corrélés à un cancer de la prostate récurrent ou non récurrent. Le système de pronostic du cancer de la prostate fournit des ensembles de séquences cibles de « pronostic du cancer de la prostate », ainsi que des combinaisons de sondes de polynucléotides et des amorces qui en sont dérivées. Ces combinaisons de sondes de polynucléotides peuvent être fournies en solution ou en tant que matrice. La combinaison de sondes et les matrices peuvent être utilisées pour le diagnostic. Linvention concerne en outre des procédés de classification de tissu du cancer de la prostate.
Genomedx Biosciences Inc.
Mbm Intellectual Property Law Llp
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