T cell receptor-based therapy for rheumatoid arthritis

Details T cell receptor-based therapy for rheumatoid arthritis T cell receptor-based therapy for rheumatoid arthritis

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) C07K 7/04 (2006.01) C07K 14/725 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2116526

2116526 9304695 PCTABS00020 There is provided by this invention a novel method of treating rheumatoid arthritis in a mammal. The method comprises the steps of obtaining a sample of synovium from the mammal; identifying in said sample T cell receptor variable regions; and administering to said mammal an effective amount of antibodies to at least one of said T cell receptor variable regions or antigenic fragments thereof. The invention further provides a novel method of treating rheumatoid arthritis in a mammal comprising the steps of administering to said mammal an effective amount of antibodies to mammalian T cell receptor variable regions selected from the group consisting of V.alpha.17, V.alpha.1, V.beta.12, V.beta.14, V.beta.17 and V.beta.7 and antigenic fragments thereof. The invention further comprises a novel method for immunizing a mammal to prevent the occurrence of rheumatoid arthritis or to treat ongoing rheumatoid arthritis. The method comprises the steps of administering to said mammal mammalian T cell receptor variable regions selected from the group consisting of V.alpha.17, V.alpha.1, V.beta.12, V.beta.14, V.beta.17, V.beta.7 and antigenic fragments thereof. Kits comprising mammalian T cell receptor variable regions selected from the group consisting of V.alpha.17, V.alpha.1, V.beta.12, V.beta.14, V.beta.17 and V.beta.7 and antigenic fragments thereof or antibodies to said variable regions are also provided by the invention.

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