C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2379345
This invention provides nucleic acids containing sequences from a TCR.gamma. transcript from prostate epithelial cells and many breast cancer cells and a T- cell receptor gamma Alternate Reading frame Protein ("TARP") expressed from the translation of those sequences. Vaccines made from TARP are useful in raising immune responses to cells in which the protein is expressed, including prostate cancer cells and cells of many breast cancers. The invention also provides methods for diagnosing the presence of prostate cancer and TARP- expressing breast cancers, as well as methods of administering TARP and nucleic acids encoding TARP to subjects.
La présente invention concerne des acides nucléiques contenant des séquences provenant d'un transcrit TCR.gamma. de cellules épithéliales de la prostate et de beaucoup de cellules du cancer du sein et une protéine cadre de lecture de substitution (TARP) de récepteur.gamma. de lymphocytes T exprimée par la traduction de ces séquences. Les vaccins fabriqués à partir de TARP conviennent pour augmenter les réponses immunitaires envers des cellules dans lesquelles la protéine est exprimée, y compris les cellules cancéreuses de la prostate et des cellules de nombreux cancers du sein. En outre, cette invention concerne des méthodes permettant de diagnostiquer la présence du cancer de la prostate et des cancers du sein exprimant TARP, ainsi que des méthodes d'administration de TARP et des acides nucléiques codant TARP aux sujets.
Brinkmann Ulrich
Essand Magnus
Lee Byungkook
Pastan Ira
Vasmatzis George
Smart & Biggar
The Government Of The United States Of America As Represented By
LandOfFree
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