C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/13 (2006.01) A61K 38/09 (2006.01) A61K 39/00 (2006.01) A61K 39/175 (2006.01) A61K 39/39 (2006.01) A61K 45/06 (2006.01) C07K 7/08 (2006.01)
Patent
CA 2361658
The present invention provides T helper cell epitopes and compositions for use in inducing an immune response comprising at least one of these epitopes. The epitopes are contained within a peptide sequence selected from the group consisting of SSKTQTHTQQDRPPQPS; QPSTELEETRTSRARHS; RHSTTSAQRSTHYDPRT; PRTSDRPVSYTMNRTRS; TRSRKQTSHRLKNIPVH; SHQYLVIKLIPNASLIE; IGTDNVHYKIMTRPSHQ; YKIMTRPSHQYLVIKLI; KLIPNASLIENCTKAEL; AELGEYEKLLNSVLEPI; KLLNSVLEPINQALTLM; EPINQALTLMTKNVKPL; FAGVVLAGVALGVATAA; GVALGVATAAQITAGIA; TAAQITAGIALHQSNLN; GIALHQSNLNAQAIQSL; NLNAQAIQSLRTSLEQS; QSLRTSLEQSNKAIEEI; EQSNKAIEEIREATQET; TELLSIFGPSLRDPISA; PRYIATNGYLISNFDES; CIRGDTSSCARTLVSGT; DESSCVFVSESAICSQN; TSTIINQSPDKLLTFIA, SPDKLLTFIASDTCPLV and SGRRQRRFAGVVLAGVA.
La présente invention concerne des épitopes de lymphocytes T auxiliaires et des compositions pour induire une réponse immune contenant au moins un de ces épitopes. Les épitopes sont contenus dans une séquence peptidique choisie dans le groupe comprenant SSKTQTHTQQDRPPQPS; QPSTELEETRTSRARHS; RHSTTSAQRSTHYDPRT; PRTSDRPVSYTMNRTRS; TRSRKQTSHRLKNIPVH; SHQYLVIKLIPNASLIE; IGTDNVHYKIMTRPSHQ; YKIMTRPSHQYLVIKLI; KLIPNASLIENCTKAEL; AELGEYEKLLNSVLEPI; KLLNSVLEPINQALTLM; EPINQALTLMTKNVKPL; FAGVVLAGVALGVATAA; GVALGVATAAQITAGIA; TAAQITAGIALHQSNLN; GIALHQSNLNAQAIQSL; NLNAQAIQSLRTSLEQS; QSLRTSLEQSNKAIEEI; EQSNKAIEEIREATQET; TELLSIFGPSLRDPISA; PRYIATNGYLISNFDES; CIRGDTSSCARTLVSGT; DESSCVFVSESAICSQN; TSTIINQSPDKLLTFIA, SPDKLLTFIASDTCPLV et SGRRQRRFAGVVLAGVA.
Jackson David Charles
Souravi Ghosh
Walker John
Commonwealth Scientific And Industrial Research Organisation
Csl Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Council Of The Queensland Institute Of Medical Research
The University Of Melbourne
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