Tace inhibitors

Details Tace inhibitors Tace inhibitors

C - Chemistry, Metallurgy

07

D

C07D 279/12 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 211/96 (2006.01) C07D 241/24 (2006.01) C07D 265/30 (2006.01)

Patent

CA 2340182

A compound of formula (I), wherein R1, R2, R3, R4, R5, R6 and Q are as defined, useful in the treatment of arthritis, cancer, and other diseases involving the dysregulated production/release of reprolysins such as TNF and other diseases characterized by matrix metalloproteinase activity. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NASAIDs), COX-2 inhibitors and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.

L'invention concerne un procédé de formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ et Q sont tels que définis ci-dessus. Ledit composé est utile dans le traitement de l'arthrite, du cancer et d'autres maladies impliquant la production/libération déréglée de reprolysines telles que TNF et d'autres maladies se caractérisant par l'activité de métalloprotéinase matricielle. Par ailleurs, le composé de l'invention peut être utilisé dans une thérapie combinée, conjointement avec des médicaments anti-inflammatoires non-stéroïdiens, et combiné à des médicaments cytotoxiques, tels que l'adriamycine, la daunomycine, le cisplatinum, l'étoposide, le taxol, le taxotère et d'autres alcaloïdes, tels que la vincristine, dans le traitement du cancer.

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