Tailored treatment suitable for different forms of mastocytosis

Details Tailored treatment suitable for different forms of mastocytosis Tailored treatment suitable for different forms of mastocytosis

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/00 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2517308

The present invention relates to a method for a tailored treatm ent of mastocytosis comprising a) assessing whether or not a c-kit mutation at position 816 is detected in a sample of a patient and b) administering a specific 816 mutant c-kit inhibitor in case a mutation is detected in step a) or an inhibitor displaying efficacy on c-kit wild in case no mutation is detected in step a). The invention is more particularly suited 10 for treating category II, III and IV mastocytosis.

Procédé de traitement individualisé de mastocytoses consistant (a) à évaluer si oui ou non une mutation du c-kit en position 816 est détectée dans un échantillon prélevé chez un patient, et (b) à administrer un inhibiteur de c-kit mutant 816 spécifique au cas où une mutation serait détectée dans l'étape (a), ou alors un inhibiteur connu pour son efficacité contre le c-kit sauvage au cas où aucune mutation ne serait détectée dans l'étape (a). L'invention convient tout particulièrement au traitement des mastocytoses de catégorie II, III et IV.

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