C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 213/10 (2006.01) C07C 217/18 (2006.01)
Patent
CA 2297246
A method of preparing a first geometric isomer of tamoxifen or an analogue comprises allowing the first isomer to crystallise in hexanol and the product thereof to crystallise in methanol and then derivatising the product of the methanol crystallisation to prepare said first isomer in very high purity.
L'invention concerne un procédé de préparation d'un premier isomère géométrique de tamoxifène ou un analogue. Ce procédé consiste à cristalliser le premier isomère dans l'hexanol et à cristalliser le produit ainsi obtenu dans du méthanol, puis à former le produit issu de la cristallisation au méthanol pour préparer ledit premier isomère à une pureté très élevée.
Double John
Maitland Derek
Popa Ioana
Kymed Gb Limited
Ridout & Maybee Llp
University Of Bradford
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