Tandem cardiac pacemaker system

Details Tandem cardiac pacemaker system Tandem cardiac pacemaker system

A - Human Necessities

61

N

A61N 1/368 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2616209

This invention provides pacemaker systems comprising (1) an electronic pacemaker, and (2) a biological pacemaker, wherein the biological pacemaker comprises a cell that functionally expresses a chimeric hyperpolarization- activated, cyclic nucleotide-gated (HCN) ion channel at a level effective to induce pacemaker current in the cell. The invention also provides related biological pacemakers, atrioventricular bridges, methods of making same, and methods of treating a subject afflicted with a cardiac rhythm disorder.

L'invention concerne des systèmes de stimulation cardiaque comprenant (1) un stimulateur électronique, et (2) un stimulateur biologique, le stimulateur biologique contenant une cellule qui exprime de façon fonctionnelle un canal ionique à hyperpolarisation chimérique activée, à porte nucléotidique cyclique HCN à un niveau efficace afin d'induire un courant de stimulation dans la cellule. L'invention concerne également des stimulateurs biologiques associés, des ponts oriculo-ventriculaires, des procédés de fabrication de ceux-ci et des procédés de traitement d'un sujet souffrant de troubles du rythme cardiaque.

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