A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2712964
Tapasin (Tpn) is a member of the MHC Class I loading complex and functions to bridge the TAP peptide transporter to MHC Class I molecules. Metastatic human carcinomas express low levels of the antigen processing components (APCs) tapasin and TAP, and display few functional surface MHC Class I molecules. As a result, carcinomas are often unrecognizable by effector cytolytic T cells (CTLs). Tpn alone can enhance survival and immunity of mammals against tumors, but additionally, Tpn and TAP can be used together as components of immunotherapeutic vaccine protocols to eradicate tumors.
La tapasine (Tpn) est un membre du complexe de chargement du CMH de classe I et sa fonction consiste à associer le transporteur de peptides TAP aux molécules du CMH de classe I. Les carcinomes métastatiques humains expriment de faibles niveaux des composants de traitement des antigènes (APC) tapasine et TAP, et présentent peu de molécules du CMH de classe I à surface fonctionnelle. Par conséquent, il est fréquent que les cellules T effectrices cytolytiques (CTL) ne soient pas capables de reconnaître les carcinomes. La Tpn seule peut améliorer la survie et l'immunité de mammifères face aux tumeurs, mais en outre, la Tnp et le TAP peuvent être utilisés conjointement en tant que composants de protocoles de vaccination immunothérapeutique destinés à éradiquer les tumeurs.
Smart & Biggar
Tapimmune Inc.
LandOfFree
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