C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) C07K 4/00 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2196679
The invention relates to a general process by which recombinantly derived variable domains of antibodies encompassing either or both light and heavy variable regions with or without respective constant regions are engineered and selected for identification of unique surface domains of pharmaceutical targets or parts thereof which regulate target function. The recombinant antibodies are useful as reagents for high volume, rapid screening of occupation of the active surface domains by natural or synthetic entities. This invention is also directed to elucidating the three-dimensional conformation of the antibodies, or parts thereof, which bind to the pharmaceutical targets and confers activity. Methods for creating high resolution molecular models which can direct the synthesis of biologically active small organic molecules useful as viable discovery drug leads are also provided.
L'invention concerne un procédé général par lequel des domaines variables d'anticorps, provenant de recombinaisons, englobant des régions variables légères et/ou lourdes, avec ou sans les régions constantes respectives, sont combinés et choisis pour identifier des domaines de surface exclusifs, propres à des cibles pharmacologiques, ou à des parties de celles-ci, qui modulent une fonction cible. Les anticorps recombinés servent de réactifs pour le triage rapide et à fort volume de l'occupation des domaines de surface actifs par des entités naturelles ou synthétiques. L'invention concerne aussi la détermination de la conformation tridimensionnelle des anticorps, ou de parties de ceux-ci, qui se lient à des cibles pharmacologiques et qui confèrent une activité. On décrit aussi des procédés permettant de créer des modèles moléculaires à haute résolution qui peuvent orienter la synthèse de petites molécules organiques biologiquement actives utiles en tant qu'amorces de découvertes de substances médicamenteuses viables.
Dgi Biotechnologies L.l.c.
Dgi Technologies Inc.
Smart & Biggar
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